Farfolex


Prescription

Instruction in English

Instruction in Khmer

Ofloxacin is a quinolone-carboxylic acid derivative with a wide range of antibacterial activity against both Gram-negative and Gram-positive organisms. It inhibits bacterial DNA replication by blocking DNA topo-isomerases, in particular DNA gyrase. Antimicrobial spectrum includes Gram-positive aerobes: Staphylococcus aureus (meticillin-susceptible), Staphylococcus epidermidis (meticillin-susceptible), Staphylococcussaprophyticus, Streptococcus pneumoniae (penicillinsusceptible), Streptococcus pyogenes.

Composition

Each 100 ml contains:

Ofloxacin BP 200 mg;

Excipients   q.s.

Indications for use

It is indicated for the treatment of the following infections when caused by sensitive organisms:

  • Respiratory tract infections (acute and chronic bronchitis, pneumonia, including those caused by intracellular or atypical pathogens, with the exception of pneumococcal infections);
  • Acute, chronic and recurrent infections of upper respiratory tract (except for cases of acute tonsillitis – strains as Streptococcus spp. moderately susceptible to ofloxacin, the drug should not be used as a tool of choice for the treatment of pneumonia caused by pneumococcus, and acute tonsillitis (ß-hemolytic streptococcus));
  • Infections of skin and soft tissue;
  • Infection of bone (osteitis, osteomyelitis) and joints;
  • Abdominal infections, including infections of the biliary tract;
  • Intestinal infections, including escherichiosis, salmonellosis, shigellosis, cholera, yersiniosis;
  • Infectious and inflammatory diseases of the pelvic organs (pelvioperitonit, salpingitis, oophoritis, tubo-ovarian abscesses, endometritis);
  • Complicated and uncomplicated infectious and inflammatory diseases of the urinary tract, prostate and urethra, including gonococcal etiology;
  • Sepsis;
  • Prevention of bacterial infections in patients with impaired immunity, including neutropenia.

Mode of administration

General dosage recommendations:

The dose of ofloxacin is determined by the type and severity of the infection. A daily dose of up to 400 mg ofloxacin may be given as a single dose. In this case, it is preferable to administer ofloxacin in the morning. Daily doses of more than 400 mg must be divided into two separate doses and be given at approximately equal intervals.

Adults:

The usual intravenous dosages in adults are:
Complicated urinary tract infection: 200 mg daily.
Lower respiratory tract infection: 200 mg twice daily.
Septicaemia: 200 mg twice daily.
Skin and soft tissue infections: 400 mg twice daily.
Farfolex solution is only intended for SLOW intravenous infusion; it is administered once or twice daily. The infusion time for Farfolex IV should not be less than 30 minutes for 200 mg.
This is of particular importance when ofloxacin is administered concomitantly with drugs that can lead to a reduction in blood pressure or with barbiturate-containing anaesthetics. Generally, individual doses are to be given at approximately equal intervals. The dose may be increased to 400 mg twice daily in severe or complicated infections.

Children: Farfolex is not indicated for use in children or growing adolescents.

Elderly: Age in itself does not impose to adapt the dosage of Farfolex. However, special attention to renal function should be paid in elderly patients, and the dosage should be adapted accordingly.